WebJun 24, 2024 · The cells were then incubated with FLAG and rH2AX antibodies for 1 h at room temperature. Following three 5-min washes with PBS, the cells were incubated with the indicated secondary antibodies ... WebAnti-phospho-Histone H2A.X (Ser139) Antibody, clone JBW301 is a highly specific mouse monoclonal antibody, that targets Histone H2A.X & has been tested in western blotting, ICC, ChIP & Immunof. MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
- 9718 - Cell Signaling Technology, Inc H2AX antibody
WebNov 29, 2013 · Radiation therapy is one of the most common and effective strategies used to treat cancer. The irradiation is usually performed with a fractionated scheme, where the dose required to kill tumour cells is given in several sessions, spaced by specific time intervals, to allow healthy tissue recovery. In this work, we examined the DNA repair … WebThis work gives new insights into the regulation of H2AX protein turnover under chronic oxidative stress that affects DNA damage response. H2AX degradation upon chronic stress sensitizes tumour cells to chemotherapy and is indicative of better survival in triple-negative breast cancer patients. ready for afit
Phospho-gamma-H2AX (Ser139) Polyclonal Antibody - Thermo Fisher Scientific
WebJan 5, 2010 · Background Evidence suggests that tumor cells exposed to some DNA damaging agents are more likely to die if they retain microscopically visible γH2AX foci … WebFeb 4, 2010 · Abstract. Phosphorylation of the Ser-139 residue of the histone variant H2AX, forming γH2AX, is an early cellular response to the induction of DNA double-strand … WebDec 2, 2024 · Here, ADP-ribosylation of histone variant H2AX on a specific residue upon oxidative damage is found to not only promote base excision repair (BER), but to also suppress γH2AX-associated DNA double-strand break (DSB) responses. Glutamate residue 141 (E141) of histone H2AX is ADP-ribosylated following oxidative DNA damage. ready for a new life